2018 Speakers

Kenneth Anderson, MD

Program Director, Dana-Farber Cancer Institute
Kraft Family Professor of Medicine, Harvard Medical School
Boston, MA

IHR 2018 Speaker
Dr. Anderson is the Kraft Family Professor of Medicine at Harvard Medical School and serves as Director of the Jerome Lipper Multiple Myeloma Center and Lebow Institute for Myeloma Therapeutics at the Dana-Farber Cancer Institute. He is a Doris Duke Distinguished Clinical Research Scientist and American Cancer Society Clinical Research Professor.

Over the last three decades, he has focused his laboratory and clinical research studies on multiple myeloma. He has developed laboratory and animal models of the tumor in it is microenvironment which have allowed for both identification of novel targets and validation of novel targeted therapies, and has then rapidly translated these studies to clinical trials culminating in FDA approval of novel targeted therapies. His paradigm for identifying and validating targets in the tumor cell and its milieu has transformed myeloma therapy and markedly improved patient outcome.

He is a recipient of many scientific and humanitarian awards including: the International Myeloma Workshop Waldenström’s Award; the International Myeloma Foundation Robert A. Kyle Lifetime Achievement Award; the American Association for Cancer Research Joseph H. Burchenal Award; the American Society of Hematology William Dameshek Prize; the Johns Hopkins Society of Scholars; election to the Royal Colleges of Physicians and of Pathologists of the United Kingdom; the American Society of Clinical Oncology David A. Karnofsky Award; the Hope Funds for Cancer Research Award of Excellence in Clinical Research; the Ron Burton Humanitarian Award; the Harvard Medical School Warren Alpert Foundation Prize; the American Cancer Society Medal of Honor in Science, the Leonard P. Zakim Patient Advocacy Award: the Samuel Waxman Research Foundation David Workman Memorial Award; the University of Miami Sylvester Cancer Center Annual Zubrod Memorial Award; and appointment as a Fellow of the American Association for Cancer Research Academy, to the Board of Scientific Advisors of the National Cancer Institute, and to the Institute of Medicine’s National Cancer Policy Forum. He is a member of the Institute of Medicine of the National Academy of Sciences, served as President of the International Myeloma Society, and is President of the American Society of Hematology.

Dr. Anderson is a graduate of Boston University and Johns Hopkins Medical School. He trained in internal medicine at Johns Hopkins Hospital, and then completed hematology, medical oncology, and tumor immunology training at the Dana-Farber Cancer Institute.

Ruemu Birhiray, MD
IHR 2018 Speaker

Partner,
Vice President,
Hematology-Oncology of Indiana, PC,
Indianapolis, Indiana

Attending Physician,
Medical Oncology, Hematology and Hematopoietic Cell Transplantation,
St. Vincent’s Hospital,
86th Street,
Indianapolis, IN 46260

Chair and Founder,
Annual Indy Hematology Review

Chief Executive Officer and Chairman,
Indy Hematology Education, Inc.

Clinical Associate Professor,
Marion University School of Osteopathic Medicine,
Indianapolis, Indiana.

Editorial Board Member: Journal of Blood Transfusion and Hematopathology Indianapolis, IN

Office Address:
Hematology-Oncology of Indiana, PC
8301 Harcourt Road, Suite 200
Indianapolis, IN 46260-2082
Tel: (317) 415 6606
Fax: (317) 415 6667
E-mail: birhiray@msn.com

Board Certification: 
American Board of Internal Medicine: 1995 - 2005
Medical Oncology: Current

Appointments:
Principal Investigator and Founder,
Research Program, Hematology Oncology of Indiana

Director, 2001-2014
Bone Marrow Transplantation Program and Blood Center,
St. Vincent Hospital, Indianapolis

Principal Investigator, 2005-2013
National Surgical Adjuvant Breast and Bowel Project (NSABP), St. Vincent Hospital, Indianapolis

Clinical Inspector,
Foundation for the Accreditation of Hematopoeitic Cell Transplantation (FAHCT).

7/1/98-6/30/01
Member/Attending Oncologist,
Division of Hematologic Malignancies/Oncology
Marshfield Clinic,
Marshfield, Wisconsin.

Director,
Bone Marrow Transplantation,
Marshfield Clinic/St. Josephs Hospital,
Marshfield, Wisconsin 

Clinical Assistant Professor of Medicine,
University of Wisconsin Medical School,
Madison, Wisconsin

7/1/2001

Associate Professor,
Bone Marrow Transplantation
Rush Medical College
Chicago, Illinois

Education:
1980-1986:
MD (MBBS), University of Benin, Benin City, Nigeria.

Residency: 1992-1995:        
Internal Medicine Residency
Columbus Hospital,
Chicago, IL
(Affiliated with Northwestern University)

Postgraduate training:

1997-1998:
Bone Marrow Transplant Fellowship
Johns Hopkins University,
Baltimore, MD

Research:
Adoptive Natural Killer cellular immunotherapy approach as consolidative therapy post bone marrow transplantation/chemotherapy.

1995-1998:
Medical Oncology Fellow,

National Cancer Institute/National Institutes of Health,

Bethesda, MD

Laboratory:
Basic science work in the transport of anti-folates particularly in hematopoetic stem cells.

Viral mediated gene transfer to modulate drug transport and enhance cell sensitivity.

In-vivo “gene therapy” in a mouse BMT model, with an attempt to control graft versus host disease using drug transfer genes

Principal Investigator:  

MAJOR PHASE III TRIALS

CLOEPATRIA TRIAL

EXENET TRIAL

APREPITANT TRIAL: Efficacy and Tolerability of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer After Moderately Emetogenic Chemotherapy

NSABP –P2 TRIAL

NSABP CO-08 TRIAL                            

Committee Memberships:   

St. Vincent Foundation Grant and Awards Committee - Current
St. Vincent Hospital Medical Executive Committee - 2005-2014
Oncology Scientific Review Committee. - 2010-2013
St. Vincent Institutional Review Board - 2001-2013
Hematopoietic Stem Cell Transplantation Committee -2001-2014

 Memberships:

Residents Council, Illinois Society of Int. Medicine (Representing Columbus Hospital) 1993-1995

 American Society of Clinical Oncology.

American Society of Hematology

American Medical Association

Wisconsin Medical Society (1998-2001)

Indiana Medical Society

Awards:

Intern of the Year - Columbus Hospital, 1993
Indianapolis Monthly Magazine” - Best Doctors in Indianapolis (Oncologist),   2006, 2013, 2014
Castle Connolly “Top Doc”
“Healing Spirit Award” – Wellness Community, 2007

Research Grants:
Amgen

Scherring -Plough

Sanofi Aventis

Genentech BioOncology

Hobbies: World history, Biking, and Travel

Personal: Married; Donna Marie: Occupational Therapist

Children: Maya Nicole Birhiray and Dirin Jeda Birhiray, and Meaghan Wiggins

Nationality: United States Citizen

References: Furnished upon request

Robert Brodsky, MD

Johns Hopkins Family Professor of Medicine and Oncology
Director, Division of Hematology, Johns Hopkins University School of Medicine
Baltimore, MD

IHR 2018 Speaker
Dr. Brodsky is the Johns Hopkins Family Professor of Medicine and Oncology Research, and a member of the Johns Hopkins Kimmel Cancer Center. He also serves as the Director of the Division of Hematology and the T32 Training Program and Director of the Physician-Scientist Pathway for the Osler Residency Program.

Dr. Brodsky received his medical degree from Hahnemann University. He completed his residency in Internal Medicine at Vanderbilt University School of Medicine and his fellowship training in hematology at the National Institutes of Health and in oncology at Johns Hopkins University.

Dr. Brodsky’s clinical and academic interests relate to bone marrow failure disorders, hemolytic anemias, and complement. He and his colleagues pioneered the use of high-dose cyclophosphamide for treating autoimmunity and alloimmunity. He has a special interest in using post-transplant cyclophosphamide to prevent graft-versus-host disease and to expand the donor pool to include HLA-haploindentical donors for aplastic anemia and severe hemoglobinopathies.

He has been recognized with numerous honors. In 2013, he received the Clinical Research Achievement Award from the Clinical Research Forum for his work in sickle cell disease. He was a Clinical Research Scholar of the Leukemia and Lymphoma Society of America in 2000. He is on the editorial board for Blood and is an Associate Editor for the Journal of Clinical Investigation. He on the Executive Committee of the American Society of Hematology (ASH) and serves as Secretary for ASH.

Bruce Cheson, MD, FACP, FAAS, FASCO

Deputy Chief, Division of Hematology/Oncology in the Department of Medicine
Head of Hematology and Professor of Medicine
Lombardi Comprehensive Cancer Center, Georgetown University Hospital
Washington, DC

IHR 2018 Speaker
Dr. Bruce Cheson, M.D., FACP, FAAS, FASCO attended the University of Virginia and then Tufts University Medical School. He completed his internship and residency in Internal Medicine at the University of Virginia Hospitals and then a clinical and research fellowship in Hematology at New England Medical Center Hospital. From 1977-1984 he was Assistant Professor of Medicine in the Division of Hematology/Oncology at the University of Utah. From 1986-2002, he was Head, Medicine Section, CTEP at the National Cancer Institute.

Currently, Dr. Cheson is Professor of Medicine, Head of Hematology, and Deputy Chief of Hematology-Oncology at Georgetown University Hospital, Lombardi Comprehensive Cancer Center. Dr. Cheson has authored over 500 medical publications and abstracts and has contributed to over 60 texts. He is Editor-in-Chief of Annals of Lymphoma, former Editor-in-Chief of Clinical Advances in Hematology, Associate Editor of the Journal of Clinical Oncology and Editor-in-Chief of Clinical Lymphoma, Leukemia and Myeloma. He is also on the editorial board of numerous journals. He has also been the editor of the American College of Physician’s Medical Knowledge Assessment Program in Oncology and the ASCO SEP. He has served on several committees of the American Society of Clinical Oncology and was on its Board of Directors, and edited ASCO News and ASCO Daily News. From 2002-2006, he was on the Oncologic Drug Advisory Committee to the U.S. Food and Drug Administration. He is past-Chair of the Lymphoma Committee of the Cancer and Leukemia Group B/Alliance, the Scientific Advisory Board of the Lymphoma Research Foundation, and the AJCC Subcommittee on Lymphoma. Dr. Cheson’s clinical interests focus on the development and evaluation of new therapeutic approaches for hematologic malignancies.

Richard Childs, MD, RADM, USPHS

Assistant U.S. Surgeon General
Clinical Director, National Heart Lung and Blood Institute
National Institutes of Health
Bethesda, MD

IHR 2018 Speaker
Rear Admiral (RADM) Richard Childs, M.D., is the Clinical Director of the National Heart, Lung, and Blood Institute’s (NHLBI) Division of Intramural Research (DIR) at the National Institutes of Health (NIH), and is the Section Chief of the Laboratory of Transplantation Immunotherapy in the NHLBI.

RADM Childs graduated from Georgetown University in Washington, D.C., in 1987 and Georgetown University Medical School in 1991. He completed his internship, residency, and a Chief Residency in internal medicine at the University of Florida in Gainesville followed by fellowships in Medical Oncology at the National Cancer Institute (NCI) and Hematology at the NHLBI. RADM Childs was appointed as a tenure-track investigator in the Hematology Branch of the NHLBI in 1999 and received tenure in 2006, when he was appointed Senior Clinical Investigator and Chief of the Section of Transplantation Immunotherapy.

Since 1995, RADM Childs has served as an officer in the United States Public Health Service (USPHS) Commissioned Corps at the NIH in the NHLBI as a physician-scientist advancing public health through medical research. RADM Childs was appointed Clinical Director of the NHLBI in 2013. The mission of the NHLBI DIR is to conduct cutting-edge research on heart, lung, blood diseases, and cancer to discover, develop, and deliver new diagnostics and therapeutics. As NHLBI’s Clinical Director, he directs and oversees the entire clinical research portfolio of the institute’s intramural research division, which is one of the largest and most clinically active institutes within the NIH. He also authored and spearheaded a multi-million dollar strategic plan that has revamped and revitalized the infrastructure supporting clinical research within the NHLBI. From December 2014 through March 2015, RADM Childs deployed to Monrovia Liberia as part of the United States Ebola Crisis response in West Africa, where he served as the Chief Medical Officer (CMO) and helped expand the supportive care capabilities of the unit by setting up its blood bank and X-ray capabilities.

In his role as a tenure-track and subsequent tenured medical researcher in the NHLBI, he has conducted bench-to-bedside studies that have shed scientific insight into cancer biology and he is recognized as an international authority in the field of tumor immunology and bone marrow transplantation. RADM Childs maintains an extremely robust laboratory and research bone marrow transplant program, has performed hundreds of experimental stem cell transplants at the NHLBI, and has published over 190 original research papers in journals such as the New England Journal of Medicine, the Lancet, Nature Medicine, and Nature.

RADM was elected into the American Society of Clinical Investigation (ASCI) in 2009, and is the recipient of numerous awards, including the NIH Director’s Scientific Medal Award, the NIH Distinguished Clinical Teacher Award and the United States Commissioned Corps’ Outstanding Service Medal and Distinguished Service Medal for research that has improved the field of hematopoietic stem cell transplantation.

Craig Kessler, MD

Professor of Medicine and Pathology
Director, Clinical Coagulation Laboratory, Division of Laboratory Medicine
Lombardi Comprehensive Cancer Center, Georgetown University Hospital
Washington, DC

IHR 2018 Speaker
Dr. Craig Kessler is a professor of Medicine and Pathology in the Division of Hematology/Oncology and Section Chief of Hematology at the Lombardi Comprehensive Cancer Center and Georgetown University Medical Center. He is also the Director of Clinical Coagulation Laboratory, Division of Laboratory Medicine, in the Department of Pathology. Dr. Kessler is an expert in internal medicine and hematology and has special interests in anemias, bleeding disorders, coagulation and platelet disorders, hematologic malignancies, myeloproliferative diseases, thrombophilias and hemophilias, and treatment of hematologic diseases.

Dr. Kessler received his medical degree from the Tulane University School of Medicine in New Orleans, Louisiana, where he was a member of Alpha Omega Alpha Honor Society. He completed his residency in internal medicine at the Ochsner Foundation Hospital in Louisiana and his fellowship in hematology/oncology at the Johns Hopkins Hospital and University in Baltimore, Maryland.

He then became a full-time faculty member and attending physician in the Section of Special Hematology at the National Institutes of Health in Bethesda, Maryland. In 1982, he joined the Division of Hematology and Oncology at the George Washington University School of Medicine, where he became tenured professor of medicine and chief of the division. In addition, Dr Kessler is director of the Division of Coagulation, director of cellular and therapeutic apheresis, director of the Hemophilia and Thrombophilia Comprehensive Treatment Center, and immediate past chief of the Division of Hematology/Oncology.

He is co-editor of Haemophilia and Seminars in Thrombosis and Hemostasis, and is chair of the Medical and Scientific Advisory Council of the National Hemophilia Foundation. Dr Kessler has been awarded Mastership in the American College of Physicians and has published more than 175 peer reviewed articles and 4 books.

Thomas Kipps, MD, PhD

Professor of Medicine
Evelyn and Edwin Tasch Chair in Cancer Research, Division of Hematology-Oncology
Deputy Director for Research Operations and Interim Director
UC San Diego Moores Cancer Center
La Jolla, CA

IHR 2018 Speaker
Thomas Kipps, MD, PhD, is Distinguished Professor of Medicine, Evelyn and Edwin Tasch Chair in Cancer Research, and Deputy Director of Research Operations at the University of California San Diego Moores Cancer Center. He received his M.D. and Ph.D. in Immunology from Harvard University and completed his residency and fellowship training in Internal Medicine, Hematology, and Genetics at Stanford University.

Dr. Kipps is internationally renowned for his translational research on immunologic approaches for the treatment of cancer and understanding the biologic mechanisms that contribute to cancer, in particular chronic lymphocytic leukemia (CLL).

Dr. Kipps has over 25 years’ experience in combining research and clinical care responsibilities, and over 350 peer-reviewed publications. As Deputy Director of Research Operations, he is working to integrate basic and translational research at the Moores Cancer Center with basic and translational scientists, clinical investigators, epidemiologists, and physicians, who offer state-of-the art therapies for patients with various forms of cancer. Dr. Kipps directs the multi-institutional, NIH-sponsored CLL Research Consortium (CRC) and directs a Specialized Center of Research in Leukemia supported by the Leukemia & Lymphoma Society. In addition, he is a two-time awardee of the NIH MERIT Award and recipient of the Binet/Rai medal for contributions in CLL research. He also is the principal investigator for a Disease Team III project sponsored by California Institute for Regenerative Medicine, in which he developed a humanized anti-ROR1 monoclonal antibody (mAb), designated UC-961 (or cirmtuzumab), for which he now holds the IND with which to conduct clinical trials examining the safety and efficacy of this mAb in the treatment of patients with cancer.

Richard Larson, MD

Professor of Medicine, Section of Hematology/Oncology
Director, Hematologic Malignancies Clinical Research Program
The University of Chicago Comprehensive Cancer Center
Chicago, IL

IHR 2018 Speaker
Richard Larson, MD, is a professor of medicine in the Section of Hematology/Oncology and director of the Hematologic Malignancies Clinical Research Program at the University of Chicago. He received his medical degree from the Stanford University School of Medicine and completed postdoctoral training in internal medicine, hematology and oncology at the University of Chicago. He was a fellow of the Leukemia Society of America and was granted a Clinical Oncology Career Development Award from the American Cancer Society.

Dr. Larson has been a member of the faculty in the Section of Hematology/Oncology and the Comprehensive Cancer Center at the University of Chicago since 1983. He was Director of the Leukemia Clinical Research Program from 1983 to 2000, when he established the adult allogeneic bone marrow transplant program. Dr. Larson is board certified in internal medicine, hematology and medical oncology, and has served as a member of the Hematology Subspecialty Board of the American Board of Internal Medicine.

Other appointments include chair of the Leukemia Committee of the Cancer and Leukemia Group B, where he directed a large portfolio of clinical trials and ancillary laboratory studies in acute and chronic leukemias and myeloma. He is a former councilor on the Executive Committee and Treasurer of the American Society of Hematology and a member of the American Society of Clinical Oncology and the American Association for Cancer Research. Dr. Larson has published more than 300 papers, reviews, and book chapters on clinical and laboratory studies in human leukemias and, in addition, has served on the editorial boards of Blood, the Journal of Clinical Oncology, and Leukemia. He is a Section Editor for Leukemia of UpToDate.

He maintains an active clinical practice at the University of Chicago Medical Center and participates actively in the training of fellows in hematology/oncology. His current research interests include clinical trials in hematologic malignancies and stem cell transplantation, experimental therapeutics, the determinants of response to therapy in leukemia and myelodysplastic syndromes, and the etiology of therapy-related leukemias.

John Leonard, MD

Associate Dean of Clinical Research and Interim Chair of Department of Medicine
Richard T. Silver Distinguished Professor of Hematology and Medical Oncology
Weill Cornell Medical College
New York, NY

IHR 2018 Speaker
John P. Leonard, MD, is the Richard T Silver Distinguished Professor of Hematology and Medical Oncology and Associate Dean for Clinical Research at the Weill Cornell Medical College. He is Vice Chairman for Clinical Research of the Department of Medicine and Associate Director of the Cancer Center at Weill Cornell Medical College and New York Presbyterian Hospital, where he also serves as Attending Physician, Chief of the Lymphoma Service, and Director of the Joint Clinical Trials Office in New York City.

Dr. John P. Leonard received his BA from Johns Hopkins University and MD from the University of Virginia School of Medicine in Charlottesville, and completed his residency in internal medicine at New York Hospital - Cornell Medical Center and Memorial Sloan-Kettering Cancer Center. Dr. Leonard completed a fellowship in hematology and oncology at Cornell, and served as chief medical resident at New York Hospital - Cornell Medical Center.

His primary research interest is in the development of novel therapeutic strategies for the treatment of lymphoma and related hematologic malignancies. Much of his work has involved the development of novel therapies for lymphoma, including monoclonal antibodies, other immune-based treatments, targeted agents, and other innovative approaches. Dr. Leonard’s research has been published in numerous medical journals, and he has served as a member of the editorial boards of Blood and Journal of Clinical Oncology, leading international journals in these fields. He is Chair of the Lymphoma Committee of the Alliance for Clinical Trials in Oncology, a multicenter cooperative group and key component of the National Cancer Institute’s National Clinical Trials Network. Dr. Leonard is an elected member of the American Board of Internal Medicine and American Society of Clinical Investigation.

John Mascarenhas, MD, MS

Associate Professor of Medicine, Myeloproliferative Disorders Program
Tisch Cancer Institute, Division of Hematology/Oncology
Icahn School of Medicine at Mount Sinai Medical Center
New York, NY

IHR 2018 Speaker
Dr. John Mascarenhas is Associate Professor of Medicine in the Myeloproliferative Disorders Program of the Tisch Cancer Institute, Division of Hematology/Oncology at the Icahn School of Medicine at Mount Sinai. He received his medical degree from New York Medical College and his master’s degree in biological sciences from Mount Sinai Graduate School. Additionally, he completed his residency training in internal medicine at Brown University and his fellowship in hematology at Mount Sinai Hospital.

Dr. Mascarenhas is a clinical investigator in malignant hematology with a focus in translational research involving the Myeloproliferative Neoplasms. Dr. Mascarenhas is primarily responsible for the clinical trials arm of the Mount Sinai School of Medicine Myeloproliferative Disorders Program. Dr. Mascarenhas has a large clinical practice of myeloid malignancies and is specifically interested in the development of novel therapies for patients with polycythemia vera, essential thrombocythemia, myelofibrosis and forms of acute myeloid leukemia. He is the Principal Investigator of over a dozen clinical trials including Phase I, II and III trials. In addition, Dr. Mascarenhas treats patients with myelodysplastic syndrome, hypereosinophilic syndrome, systemic mastocytosis, chronic myelomonocytic leukemia and related issues.

He also serves as the Principal Investigator of the clinical trials arm of the National Cancer Institute sponsored Myeloproliferative Disorder Research Consortium. Dr. Mascarenhas serves on clinical trials steering committee for Incyte and on a DSMB for Novartis. Clinical trial funding is paid to the institution from Incyte, Novartis, Roche, Promedior, Janssen and CTI Biopharma.

Linda Nielsen, DNP, APN

Advanced Oncology Nurse Practitioner
Hematology Oncology of Indiana
Indianapolis, IN

IHR 2018 Speaker
Dr. Linda Nielsen received her doctorate of nursing practice from Purdue University. Her research was on the application of an implementation framework in a survivorship program in a community oncology clinic. She is an Advanced Oncology Certified Nurse Practitioner with Hematology Oncology of Indiana. Her 33 years of clinical experience include hematology/oncology, pain management, addictions, psychiatric care, medical/surgical, home care, geriatrics, ER, hospice, pain management, trauma, cardiac and burn unit. She currently works in a community oncology clinic with 8 other providers with a primary population of general medical hematology-oncology patients. She participates in clinical research trials and has presented on a number of hematology topics.

Paul Richardson, MD

Clinical Program Leader and Director, Dana-Farber Cancer Institute
R.J. Corman Professor of Medicine, Harvard Medical School
Boston, MA

IHR 2018 Speaker
Dr. Paul Richardson, MD, is the RJ Corman Professor of Medicine at Harvard Medical School and Clinical Program Leader and Director of Clinical Research of the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute (DFCI), Boston, USA.

Paul obtained his medical degree from St. Bartholomew’s Hospital Medical College, University of London, before completing residencies at Newcastle University School of Medicine, the Royal Marsden Hospital (London and Surrey) and the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA. His Fellowships in haematology/oncology and medical oncology were completed at Tufts University School of Medicine, Baystate Medical Center, Springfield, USA, and at Harvard Medical School, DFCI.

Paul’s primary research interest is in novel therapies for myeloma, including bortezomib, lenalidomide and pomalidomide, and most recently in the development and approval of panobinostat, elotuzumab, daratumumab and ixazomib, as well as the use of combination therapies in the treatment of this disease, particuarly in the relapsed and refractory setting. He is serving as Principal/Co-Principal Investigator and Study Chair for several pivotal trials, including the landmark international Intergroupe Francophone du Myélome/DFCI 2009 study for newly diagnosed patients eligible for stem cell transplantation (SCT), using the combination of lenalidomide, bortezomib and dexamethasone (RVD), which has provided the basis for better understanding the role of SCT in the era of novel agents.

Perhaps less well known is his role in the development of defibrotide for the treatment of veno-occlusive disease as a complication of SCT, which began with its very inception, when he treated the first patient and then led the first clinical study for this indication. Since then he has had a central role in most of the prospective clinical trials performed to date, including the pivotal trial leading to regulatory approval, with a number of orphan product drug grants awarded to him by the FDA (USA) to facilitate the development of the drug as part of his investigator initiated studies supporting approval.

Paul was awarded an honorary Fellowship of the Royal College of Physicians (UK) for his contributions in hematology (2009), and was Chair of the Multiple Myeloma Research Consortium (USA) Clinical Trials Core for five years from 2004, currently serving on its Steering Committee and Project Review Committee. He is also Chair of the Alliance Myeloma Committee (USA) and has served in this role since 2011. He is a former editorial board member of the Journal of Clinical Oncology and The Oncologist, and currently serves as associate editor for the British Journal of Haematology, having himself published authored or co-authored over 580 peer-reviewed original articles, reviews and chapters. Among numerous awards and prizes, some of the most notable include the Warren Alpert Prize in Medicine (Harvard Medical School) 2012, the Ernest Beutler Prize (the American Society of Hematology) 2015, and the COMY International Award for Contributions in Myeloma 2016. This year he was awarded the Robert Kyle Life Time Achievement Award by the IMF for his contributions to myeloma research, advances in treatment and patient care.

Martin Tallman, MD

Chief of Leukemia Service, Memorial Sloan-Kettering Cancer Center
Professor of Medicine, Weill Cornell Medical College
New York, NY

IHR 2018 Speaker
Martin S. Tallman, M.D., is Chief of Leukemia Service at Memorial Sloan-Kettering Cancer Center and Professor of Medicine at the Weill Cornell Medical College in New York. He is a diplomate of the American Board of Internal Medicine with sub-specialty certification in areas of hematology and medical oncology. He also served as Chair of the Leukemia Committee of the Eastern Cooperative Oncology Group for 16 years.

Dr. Tallman received his bachelor’s degree in Science at the University of Michigan in Ann Arbor, Michigan, and his medical degree at The Chicago Medical School in Chicago, Illinois. After completing an internship, residencies, and chief residency at McGraw Medical Center at Northwestern University, Dr. Tallman completed his fellowship in hematology/oncology at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, Washington.

Dr. Tallman is a member of numerous committees of national, regional, and international professional societies involved in the study and treatment of cancer, including the American Society of Hematology, American Society of Clinical Oncology, and the Eastern Cooperative Oncology Group. He currently serves as Co-Chair of the Acute Myeloid Leukemia Panel of the National Comprehensive Cancer Network (NCCN).

Dr. Tallman has contributed a large body of work to the literature addressing the diagnosis, biology, and treatment of acute leukemia and other hematologic malignancies. This work includes original research articles in peer-reviewed journals, textbook chapters and reviews, monographs, editorials, and abstracts. He has spoken as an invited lecturer and chair at many national and international symposia, conferences, and meetings, including the American Society of Hematology Meeting, the American Society of Clinical Oncology Meeting, and the CIBMTR Tandem Annual Meeting. Dr. Tallman completed two terms as an Associate Editor of Blood. He is a reviewer for many professional publications, including American Journal of Hematology, Annuals of Internal Medicine, Bone Marrow Transplantation, Cancer Research, Journal of Clinical Oncology, and New England Journal of Medicine. He also serves as the Editor-in-Chief of Clinical Haematology: Best Practice and Research.

Ayalew Tefferi, MD, PhD

Professor of Hematology and Internal Medicine
Mayo Clinic
Rochester, MN

IHR 2018 Speaker
Dr. Ayalew Tefferi, MD, was born in Addis Ababa, Ethiopia, and migrated to the United States in 1982 after completing his medical school education at the University of Athens in Greece. Dr. Tefferi received his hematology training at Mayo Clinic before joining the faculty at Mayo Clinic College of Medicine, Division of Hematology, in the Department of Medicine. He is currently a full professor in hematology and internal medicine.

Dr. Tefferi is primarily engaged in direct patient care. His clinical and laboratory interests focus on myeloid disorders including polycythemia vera, essential thrombocythemia, myelofibrosis, chronic myeloid leukemia, myelodysplastic syndrome, acute leukemia, and the atypical myeloproliferative disorders including hypereosinophilic syndrome and systemic mastocytosis.

His academic and research achievements have been copious and include over 800 publications including books, book chapters, original articles, reviews, editorials, letters, and abstracts. Dr. Tefferi serves as an associate or section editor for the Mayo Clinic Proceedings, Leukemia, American Journal of Hematology, and European Journal of Hematology. He also participates in the editorial board of several journals including Blood, Cancer, Leukemia Research, Acta Haematologica, and Leukemia and Lymphoma. Dr. Tefferi has given more than 500 national and international invited lectureships and serves as faculty for the annual Hematology and Oncology Board review courses at George Washington University in Washington DC, Harvard in Boston, Massachusetts, and MD Anderson Cancer Center in Houston, Texas.

Steven Treon, MD, PhD

Director, Bing Center for Waldenström’s Macroglobulinemia
Senior Physician, Dana-Farber Cancer Institute
Professor of Medicine, Harvard Medical School
Boston, MA

IHR 2018 Speaker
Dr. Steven Treon is the Director of the Bing Center for Waldenström’s Macroglobulinemia and a Senior Physician at the Dana-Farber Cancer Institute and Brigham and Women’s Hospital in Boston, Massachusetts. He is also a Professor of Medicine at Harvard Medical School, and is the Chair of the Waldenström's Macroglobulinemia Clinical Trials Group.

Dr. Treon earned his MD and PhD degrees with honors from the Boston University School of Medicine. He completed an internship in medicine and a residency in internal medicine at Boston University Medical Center, a clinical fellowship in Hematology and Medical Oncology at the Massachusetts General Hospital, and a Research Fellowship at Dana-Farber Cancer Institute and Harvard Medical School.

Dr. Treon's main research interests focus on understanding the genetic basis and pathogenesis of Waldenström’s Macroglobulinemia (WM) and the development of therapeutics for this malignancy. Using whole-genome sequencing, his laboratory first defined the genomic basis for WM that included the identification of highly prevalent activating mutations in MYD88 and CXCR4. Dr. Treon’s laboratory also identified that Bruton’s Tyrosine Kinase (BTK) was a downstream target of mutated MYD88. This finding enabled a clinical trial led by Dr. Treon that received the first ever breakthrough designation by the FDA, and subsequent fast track approval of the BTK inhibitor ibrutinib by the U.S. FDA and the European Medicines Agency. Dr. Treon’s work also showed that the mutation status of MYD88 and CXCR4 could be used as predictive markers for ibrutinib treatment response in WM. His current efforts are focused on defining the transcriptome and epigenome of WM, and the development of inhibitors that target MYD88 and CXCR4 signaling in WM.

Dr. Treon has served as the principal organizing chair of the International Workshops on WM. He is an active educator, and has taught broad audiences across the globe on the genetic basis, biology and therapy of WM. Dr. Treon has also published extensively on topics in WM and related disorders, with over 250 peer-reviewed original reports, authoritative reviews, editorials, and chapters included in many high-impact journals and textbooks. Dr. Treon has been honored with research and academic awards from various national and international medical foundations and institutions, including the Robert A. Kyle Award for Waldenström's Macroglobulinemia, the Jan Gosta Waldenström Lifetime Achievement Award, the Laurie Strauss Leukemia Foundation Outstanding Cancer Investigator Award, and the “One-Hundred Award” by the Massachusetts General Hospital. Dr. Treon has also been designated as one of “America’s Top Doctors” by U.S. News and World Report.

Michael Wiemann, MD, FACP

President, Providence Hospital
Executive Vice President West Region
St. John Providence Health System
Warren, MI

IHR 2018 Speaker
Michael C. Wiemann, MD, FACP, serves as Executive Vice President of Medical Affairs and Chief Medical Officer of St. John Providence Health System, Executive Vice President of the Providence West Region, and the President of Providence Hospital. Prior to joining St. John Health, Dr. Wiemann served as Senior Vice President and Chief Medical Officer at St. Vincent Hospitals and Health Care Center in Indianapolis. While at St. Vincent, Dr. Wiemann served on numerous quality improvement and other committees. At the national level, he continues to serve on several Ascension Health committees. In 2006 and 2007, the Consumers' Research Council of America in Washington, D.C., named him one of "America's Top Physicians in Medical Oncology."

After receiving his medical degree from Louisiana State University School of Medicine in Shreveport, he completed his internship and residency and served as Chief Resident in Internal Medicine at LSU Medical Center and the Veterans Administration Hospital in Shreveport. He then became a fellow in Medical Oncology at Roger Williams General Hospital at Brown University in Providence, Rhode Island. After completion of his fellowship, he joined the faculty as Medical Oncologist and Professor at Brown University School of Medicine. Among other leadership positions, he served as Director of the Bone Marrow Transplant Program at Roger Williams General Hospital and as the associate director of Brown’s NCI-designated cancer center.

He was subsequently recruited to St. Vincent to serve as its first medical director of oncology. During his more than 20 years in this position, he oversaw the construction of the St. Vincent inpatient hospice and the Oncology Center and established the bone marrow transplant program. He also was the principal investigator for the Ascension Health/St. Vincent National Community Cancer Center Program. Dr. Wiemann’s publications reflect his research interests in bone marrow transplant and immunotherapeutics for the treatment of renal cell carcinoma and metastatic melanoma. He is widely published in peer-reviewed journals including Blood, Cancer Research, Cancer Biotherapy and Radiopharmaceuticals, Cancer, European Journal of Gynaecological Oncology, and Gynecologic Oncology. He has contributed numerous invited reviews and book chapters and delivered presentations both nationally and internationally.


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